Stipple Effect is a pixel art editor that will change your workflow with its approach to scripting. It has all the standard features of a raster graphics editor, as well as features specifically intended to support you in making pixel art for video games or online distribution.
Scripting
Easy to read and write

Short and simple scripts with no boilerplate code
Custom previews

Write scripts to transform the contents the project canvas to generate custom previews
Simulate post-processing effects

Simulate lighting, texture UV mapping, or any other post-processing your asset may undergo in a game engine with the graphics capabilities of the Stipple Effect API
Updated dynamically in real time

Scripted previews are recomputed instantly whenever the project is edited
Turn previews into projects

Convert the output of a preview script transformation into a project - optionally with individual layers preserved
Animation
Onion skins

Animation aids that visualize preceding and following frames
Configure the onion skin settings for preceding and following skins independently
Split & stitch

Use the split frames feature to instantly slice a sprite sheet into an animation
"Stitch" frames together to turn an animation into a sprite sheet
Colors & Painting
Two-color system

Tools are designed to easily leverage the primary and secondary color
Combine the system colors with dither, blend and noise brush modes
Shade brush

The shade brush replaces the color it brushes over with the color next to it in the active palette
Palettization

Map the pixels in a given scope to their nearest neighboring color in the active palette
Dynamic gradient brush

The gradient tool has a brush mode: gradient updates itself as the brush stroke gets longer
Script brush

The script brush uses a script defining a color to color mapping to determine its behaviour
Selection
Pixel-perfect selections

Four complementary selection tools designed to quickly capture the exact set of pixels you want
Intuitive outlining

And much more...